abstract：:Mechanical forces influence articular cartilage structure by regulating chondrocyte activity. Mechanical stimulation results in activation of an alpha5beta1 integrin dependent intracellular signal cascade involving focal adhesion kinase and protein kinase C, triggering the release of interleukin-4 from the cell. In no...

journal_title：Biorheology

authors： Salter DM,Wright MO,Millward-Sadler SJ

更新日期：2004-01-01 00:00:00

abstract：:While not generally viewed as physiologically significant in articular cartilage, substantial tension can develop in fibrocartilage structures and in articular cartilage injuries. This study examined how different amplitudes of cyclic tension influence chondrocyte matrix synthesis. Bovine articular chondrocytes seeded...

journal_title：Biorheology

authors： Connelly JT,Vanderploeg EJ,Levenston ME

更新日期：2004-01-01 00:00:00

abstract：:We previously reported that intraarticular injections of hyaluronan (HA), administered prophylactically to dogs in whom knee osteoarthritis had been induced by transection of the anterior cruicate ligament, did not significantly modify the intraarticular pathology but decreased the proteogylcan concentration of the ar...

journal_title：Biorheology

authors： Brandt KD,Smith GN,Myers SL

更新日期：2004-01-01 00:00:00

abstract：:Over the past several decades, blood-soluble drag reducing polymers (DRPs) have been shown to significantly enhance hemodynamics in various animal models when added to blood at nanomolar concentrations. In the present study, the effects of the DRPs on blood circulation were tested in anesthetized rats exposed to acute...

journal_title：Biorheology

authors： Kameneva MV,Wu ZJ,Uraysh A,Repko B,Litwak KN,Billiar TR,Fink MP,Simmons RL,Griffith BP,Borovetz HS

更新日期：2004-01-01 00:00:00

abstract：:The effects of platelet margination and enhanced platelet diffusivity, as induced by red blood cells, on the adhesion of platelets, were investigated for a range of haematocrits, under 2D axi-symmetric flow, simulating previous in vitro experiments [Microvasc. Res. 17 (1979), 238-262]. The effect of margination was in...

journal_title：Biorheology

authors： Jordan A,David T,Homer-Vanniasinkam S,Graham A,Walker P

更新日期：2004-01-01 00:00:00

abstract：:Platelet margination (enhanced platelet concentration in the near wall region of a blood vessel) has been well documented in small vessels. In artery-sized vessels margination has only been demonstrated in one study, using ghost cell suspensions and under relatively non-physiologic conditions of steady flow and 50 cm ...

journal_title：Biorheology

authors： Xu C,Wootton DM

更新日期：2004-01-01 00:00:00

abstract：:The goal of this study was to determine the duration of time that ligaments from a study group need to be loaded in order to adequately determine their collective viscoelastic behavior. Rat ligaments were subjected either to creep or stress relaxation for 1,000 s or stress relaxation for 10,000 s to compare estimates ...

journal_title：Biorheology

authors： Manley E Jr,Provenzano PP,Heisey D,Lakes R,Vanderby R Jr

更新日期：2003-01-01 00:00:00

abstract：:Conducting experiments on very soft biological tissues can be difficult. Traditionally, unconfined compression and shear have been used. Here, an improved method of compression testing, lubricated squeezing flow is described. This gives a uniform compression along the squeezing axis and almost uniform equi-biaxial elo...

journal_title：Biorheology

authors： Nasseri S,Bilston L,Tanner R

更新日期：2003-01-01 00:00:00

abstract：:The aim of this study was to investigate the effect of hydrostatic pressure on the expression of messenger ribonucleic acid (mRNA) for specific extracellular matrix proteins in chondrocytes. Chondrocytes obtained from bovine metatarsophalangeal joints were embedded in cylindrical 2% agarose gels. A novel experimental ...

journal_title：Biorheology

authors： Toyoda T,Seedhom BB,Kirkham J,Bonass WA

更新日期：2003-01-01 00:00:00

abstract：:The role of clustered of L-selectin receptors on the leukocyte surface is discussed in connection with the postulated velocity-dependent formation of selectin-ligand tether bonds to interpret the mechanism of leukocyte tethering to, and rolling along, the vascular endothelium. The distinct feature of this step-wise pr...

journal_title：Biorheology

authors： Riha P,Dumas D,Latger V,Muller S,Stoltz JF

更新日期：2003-01-01 00:00:00

abstract：:This study aims at quantifying the cellular mechanical properties based on a partitioning of the cytoskeleton in a cortical and a cytosolic compartments. The mechanical response of epithelial cells obtained by magnetocytometry - a micromanipulation technique which uses twisted ferromagnetic beads specifically linked t...

journal_title：Biorheology

authors： Laurent VM,Planus E,Fodil R,Isabey D

更新日期：2003-01-01 00:00:00

abstract：:Blood vessels are always subjected to hemodynamic stresses including blood pressure and blood flow. The cerebral artery is particularly sensitive to hemodynamic stresses such as pressure and stretch, and shows contractions that are myogenic in nature; i.e., the mechanical response is generated by the vascular smooth m...

journal_title：Biorheology

authors： Nakayama K,Obara K,Tanabe Y,Saito M,Ishikawa T,Nishizawa S

更新日期：2003-01-01 00:00:00

abstract：:Skeletal muscle tissue is highly susceptible to sustained compressive straining, eventually leading to tissue breakdown in the form of pressure sores. This breakdown begins at the cellular level and is believed to be triggered by sustained cell deformation. To study the relationship between compressive strain-induced ...

journal_title：Biorheology

authors： Bouten CV,Breuls RG,Peeters EA,Oomens CW,Baaijens FP

更新日期：2003-01-01 00:00:00

abstract：:It has been hypothesized that bone cells have a hyaluronic acid (HA) rich glycocalyx (cell coat or pericellular matrix) and that this contributes to bone cell mechanotransduction via fluid flow. The glycocalyx of bone cells of the MC3T3-E1 osteoblastic cell line and the MLO-Y4 osteocytic cell line were characterized. ...

journal_title：Biorheology

authors： Reilly GC,Haut TR,Yellowley CE,Donahue HJ,Jacobs CR

更新日期：2003-01-01 00:00:00

abstract：:This study examined the effects of mechanical compression on engineered cartilage in a novel hybrid culture system. Cylindrical holes were cut in discs of bovine articular cartilage and filled with agarose gels containing chondrocytes. These constructs were compressed in radiolabeled medium under static or oscillatory...

journal_title：Biorheology

authors： Hunter CJ,Levenston ME

更新日期：2002-01-01 00:00:00

abstract：:It is widely accepted that whilst exhibiting clinically useful anti-inflammatory and analgesic activity, the application of non-steroidal anti-inflammatory drugs (NSAIDs) does not affect the underlying pathogenesis of articular diseases such as rheumatoid arthritis. The demonstration of a role for COX-2 in the resolut...

journal_title：Biorheology

authors： Colville-Nash PR,Willoughby DA

更新日期：2002-01-01 00:00:00

abstract：:The purpose of the present study was to investigate the intracellular IL-1beta production and beta1 integrins (alpha4/beta1 and alpha5/beta1) expression on chondrocytes. Chondroytes monolayer (human chondrosarcoma cell line HEM-C55) were incubated for 12, 24 and 48 hours in the presence of Tumor Necrosis Factor-alpha ...

journal_title：Biorheology

authors： Gigant-Huselstein C,Dumas D,Payan E,Muller S,Bensoussan D,Netter P,Stoltz JF

更新日期：2002-01-01 00:00:00

abstract：:This paper proposes a model for wall shear stress in arterial stenosis based on boundary layer theory. Wall shear stress estimates are obtained by solving the momentum integral equation using the method proposed by Walz and applying this method to various stenosis geometries for Reynolds numbers (Re) of Re = 59-1000. ...

journal_title：Biorheology

authors： Provenzano PP,Rutland CJ

更新日期：2002-01-01 00:00:00

abstract：:Flow induced shear stress influences vascular cellular biology and pathophysiology in numerous ways. Previous in vitro studies on interactions between flow and endothelial cells using parallel-plate flow chambers involve two-dimensional flows, whereas flows in larger vessels are commonly three-dimensional. We have con...

journal_title：Biorheology

authors： Watkins NV,Caro CG,Wang W

更新日期：2002-01-01 00:00:00

abstract：:Through cardiac looping during embryonic development, human and other vertebrate hearts adopt sinuous curvatures with marked changes in direction of flow at atrial, ventricular and arterial levels. We used magnetic resonance phase velocity mapping to study flow through the hearts of resting volunteers, and Doppler ult...

journal_title：Biorheology

authors： Kilner PJ,Yang GZ,Firmin DN

更新日期：2002-01-01 00:00:00

abstract：:The blood flow immediately adjacent to the wall of a blood vessel or an artificial surface is of great interest. This flow defines the shear stress at the wall and is known to have a great physiological importance. The use of models is a viable method to investigate this flow. However, even in models the shear stress ...

journal_title：Biorheology

authors： Affeld K,Kertzscher U,Goubergrits L

更新日期：2002-01-01 00:00:00

abstract：:In this paper we shall describe new mechanical models for the deformation of the actin filament bundles in kidney microvilli and osteocytic cell processes to see whether these cellular extensions, like the stereocilia on hair cells in the inner ear, can function as mechanotransducers when subject to physiological flow...

journal_title：Biorheology

authors： Weinbaum S,Guo P,You L

更新日期：2001-01-01 00:00:00

abstract：:It has long been recognized that understanding the rheological properties of blood is essential to a full understanding of the function of the circulatory system. Given the difficulty of obtaining carefully controlled measurements in vivo, most of our current concepts of the flow behavior of blood in vivo are based on...

journal_title：Biorheology

authors： Bishop JJ,Popel AS,Intaglietta M,Johnson PC

更新日期：2001-01-01 00:00:00

abstract：:This study investigated the changes in biorheological characteristics of skin after expansion. Expanders were implanted into the back of eight adult dogs, and after an eight-week expansion the expanded and the non-expanded control skins were transferred to an adjacent site. The expanded specimens and their controls we...

journal_title：Biorheology

authors： Zeng Y,Huang K,Xu C,Zhang J,Sun G

更新日期：2001-01-01 00:00:00

abstract：:Articular cartilage is a tissue designed to withstand compression during joint movement and, in vivo, is subjected to a wide range of mechanical loading forces. Mechanosensitivity has been demonstrated to influence chondrocyte metabolism and cartilage homeostasis, but the mechanisms underlying mechanotransduction in t...

journal_title：Biorheology

authors： D'Andrea P,Calabrese A,Capozzi I,Grandolfo M,Tonon R,Vittur F

更新日期：2000-01-01 00:00:00

abstract：:The maintenance of articular cartilage integrity requires a balance between anabolic and catabolic processes which are under the control of chondrocytes. These cells are living in an anaerobic environment and normally do not divide. They are responsible for the continuous maintenance of the cartilage extracellular mat...

journal_title：Biorheology

authors： Pujol JP,Felisaz N,Boumediene K,Ghayor C,Herrouin JF,Bogdanowicz P,Galera P

更新日期：2000-01-01 00:00:00

abstract：:Frozen, stored mucus has been extensively used for transport studies but there is no clear evidence of the influence that the temperature and length of time of storage may have on the results. We stored frog mucus samples at -20 and -80 degrees C and analysed them on days zero, 2, 10, 30 and 90. At each temperature, a...

journal_title：Biorheology

authors： Gastaldi AC,Jardim JR,King M

更新日期：2000-01-01 00:00:00

abstract：:The purpose of this study was to examine the theoretical impact of the local bifurcation geometry on the shear rate gradient in a divergent arteriolar-type bifurcation. Newtonian flow through an arteriolar bifurcation was modeled using 3-dimensional computational fluid dynamics (CFD). Branching angles of 30 degrees, 5...

journal_title：Biorheology

authors： Noren D,Palmer HJ,Frame MD

更新日期：2000-01-01 00:00:00

abstract：:Flow-dependent concentration or depletion of atherogenic low density lipoproteins which has been theoretically predicted to occur at a blood/endothelium boundary may play an important role in the genesis, progression, and regression of atherosclerosis in man and intimal hyperplasia in vascular grafts implanted in the ...

journal_title：Biorheology

authors： Naiki T,Sugiyama H,Tashiro R,Karino T

更新日期：1999-01-01 00:00:00

abstract：:Arterial hemodynamic forces may play a role in the localization of early atherosclerotic lesions. We have been developing numerical techniques based on overset or "Chimera" type formulations to solve the Navier-Stokes equations in complex geometries simulating arterial bifurcations. This paper presents three-dimension...

journal_title：Biorheology

authors： Cheer AY,Dwyer HA,Barakat AI,Sy E,Bice M

更新日期：1998-11-01 00:00:00

abstract：:The aim of this study was to investigate the effects of a surgical limb lengthening procedure on the biorheological features of some lengthened soft tissues. In this procedure external fixators were applied to goats' right radius to stretch the tissues. The right forelegs of goats were lengthened by 2, 4 cm, respectiv...

journal_title：Biorheology

authors： Huang K,Zeng Y,Xia H,Liu C

更新日期：1998-07-01 00:00:00

abstract：:Hematocrit distribution and red blood cell aggregation are the major determinants of blood flow in narrow tubes at low flow rates. It has been observed experimentally that in microcirculation the hematocrit distribution is not uniform. This nonuniformity may result from plasma skimming and cell screening effects and a...

journal_title：Biorheology

authors： Das B,Johnson PC,Popel AS

更新日期：1998-01-01 00:00:00

abstract：:Shear stress-induced platelet aggregation requires von Willebrand factor (vWF), platelet glycoprotein (GP) Ib, GPIIb-IIIa, Ca2+, and adenosine diphosphate (ADP). Recent reports using vWF labeled with either 125I or fluorescein isothiocyanate (FITC) have demonstrated that in shear-fields, vWF binds to both GPIb and GPI...

journal_title：Biorheology

authors： Konstantopoulos K,Chow TW,Turner NA,Hellums JD,Moake JL

更新日期：1997-01-01 00:00:00

abstract：:Stress relaxation in three varieties of cherries was studied using the penetration test with a cylindrical pin, 4 mm in diameter, having a flat tip. One half of the fruit was modified by partial skinning, since experiments show that skin approximately doubles the apparent modulus of elasticity of the cherries. The ski...

journal_title：Biorheology

authors： Blahovec J

更新日期：1996-11-01 00:00:00

abstract：:The well-known S-shaped settling curves are obtained as solutions of an autonomic dynamical system deduced mathematically from the generalized Stokes formula, the blood volume conservation law, and the Smoluchowski theory of particle coagulation. Numerical computations and parametric analysis of the deduced two nonlin...

journal_title：Biorheology

authors： Petrov VG,Edissonov I

更新日期：1996-07-01 00:00:00

abstract：:Elevated shear stress levels in pathologically stenosed vessels induce platelet activation and aggregation, and may play a role in the pathogenesis of arterial disease. Increased plasma catecholamine concentrations have also been implicated in the onset of acute coronary ischemic syndromes. This study was designed to ...

journal_title：Biorheology

authors： Wagner CT,Kroll MH,Chow TW,Hellums JD,Schafer AI

更新日期：1996-05-01 00:00:00

abstract：:Using a large scale model and the concept of dimensional similarity, we have developed a dimensionless correlation which permits the estimation of the drag force of blood flow in an in vivo vessel on a leukocyte adherent to the vessel wall. This relationship is [formula: see text] where Re is a Reynolds number, Cd is ...

journal_title：Biorheology

authors： Chapman G,Cokelet G

更新日期：1996-03-01 00:00:00

abstract：:In vitro experiments were conducted to measure the oscillatory flow pressure gradient along an elastic tube in order to assess the recent nonlinear theory of Wang and Tarbell. According to this theory, in an elastic tube with oscillatory flow, the mean (time-averaged) pressure gradient cannot be calculated using Poise...

journal_title：Biorheology

authors： Cohen MI,Wang DM,Tarbell JM

更新日期：1995-07-01 00:00:00

abstract：:The structure of pulsatile flow in a rigid aortic bifurcation model was studied by means of a flow visualization technique and three-dimensional laser-Doppler anemometry. The model was made of glass, having the same shape as that of the average human aortic bifurcation. It was installed into a mock circulatory loop th...

journal_title：Biorheology

authors： Naiki T,Hayashi K,Takemura S

更新日期：1995-01-01 00:00:00

abstract：:Flow-induced changes in the red cell microstructure of human blood are identified from mechanical and optical evidence. On initiation of steady flow, a new microstructure develops as the shear strain increases through unit strain. This structure is identified with the formation of layers of red cells that slide on pla...

journal_title：Biorheology

authors： Thurston GB

更新日期：1994-03-01 00:00:00